Abstract #4495

Intrinsic susceptibility MRI detects phenotypic alteration induced by a potent anaplastic lymphoma kinase inhibitor in a transgenic model of neuroblastoma

Yann Jamin¹, Elizabeth R. Tucker², Evon Poon², Alexander Koers², Laura S. Danielson², Louis Chesler², and Simon P. Robinson¹

¹Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, London, United Kingdom, ²Division of Cancer Therapeutics and Division of Clinical Studies, The Institute of Cancer Research, London, London, United Kingdom

In this study we demonstrate that the transverse relaxation rate R₂* affords a biomarker of response to a potent anaplastic lymphoma kinase inhibitor in the Th-ALK^F1174L/Th-MYCN genetically engineered murine model of neuroblastoma, a childhood cancer of the nervous system

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