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Abstract #4500

Diffusion MRI can provide non-invasive early biomarkers of the outcome of irreversible electroporation tumor treatment in a mouse model.

Matteo Figini1, Zhanliang Su1, Tianchu Lyu1, Xifu Wang1, Xiaoke Huang1, Daniel Procissi1, Andrew Christian Larson1, and Zhuoli Zhang1

1Radiology, Northwestern University, Chicago, IL, United States

This study investigates diffusion MRI changes after treatment with irreversible electroporation (IRE) in a murine cancer model. The mean and standard deviation of the ADC in regions of interest covering the whole tumors increased 1 day after treatment and then returned gradually to the pre-treatment values. A strong correlation was found between the volume increase and the maximum relative change in ADC mean and standard deviation. Therefore we propose diffusion MRI as an early tool to predict the outcome of IRE treatment in tumors.

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