Abstract #4501

Extracting oxygen-enhancing components from OE-MRI using ICA

Firas Moosvi¹, Jennifer H.E. Baker², Andrew Yung³, Piotr Kozlowski³, and Stefan Reinsberg¹

¹Department of Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, ²Department of Integrative Oncology, BC Cancer Research Centre, ³UBC 7T MRI Research Centre, University of British Columbia

MRI methods to assess tissue oxygenation have recently flourished. Here we explore how a common signal processing technique (independent component analysis) can be used to extract and amplify signal from oxygen stimuli in mouse tumours. With just dynamic T1-weighted images and ICA to extract the enhancing pixels, we can create rich parameter maps corresponding to a response to an oxygen challenge.

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