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Abstract #4501

Extracting oxygen-enhancing components from OE-MRI using ICA

Firas Moosvi1, Jennifer H.E. Baker2, Andrew Yung3, Piotr Kozlowski3, and Stefan Reinsberg1

1Department of Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, 2Department of Integrative Oncology, BC Cancer Research Centre, 3UBC 7T MRI Research Centre, University of British Columbia

MRI methods to assess tissue oxygenation have recently flourished. Here we explore how a common signal processing technique (independent component analysis) can be used to extract and amplify signal from oxygen stimuli in mouse tumours. With just dynamic T1-weighted images and ICA to extract the enhancing pixels, we can create rich parameter maps corresponding to a response to an oxygen challenge.

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