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Abstract #4502

Extracellular-extravascular accumulation of non-caloric sweetener (sucralose) provides CEST contrast for cancer detection

Puneet Bagga1, Mohammad Haris2, Kevin D'Aquilla1, Francesco Marincola2, Hari Hariharan1, and Ravinder Reddy1

1Department of Rediology, University of Pennsylvania, Philadelphia, PA, United States, 2Research Branch, Sidra Medical and Research Center, Doha, Qatar

We show the utility of a non-nutritive sweetener, sucralose, as a contrast agent in cancer MRI studies by exploiting its chemical exchange saturation transfer (sucCEST) property. The extracellular-extravascular accumulation of sucralose in a glioma model provides localized, temporal changes in the CEST contrast, corroborating the gadolinium-enhanced MRI. These findings illustrate the potential of sucCEST for diagnosis and monitoring of the therapeutic response of cancers, including gliomas in preclinical studies.

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