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Abstract #4505

A novel DTI derived heterogeneity index discriminating liver metastasis from normal appearing liver tissue: a PET-MRI study

DAN STEIN1,2, Natalia Goldberg 1, Liran Domachevsky 1, Hanna Bernstine1, Meital Nidam 1, Dorit Stern 1, Ifat Abadi-Korek1, Jacob Sosna , and David Groshar1

1Radiology, Assuta Medical Center, Tel-Aviv, Israel, 2Anatomy & Anthropology, Tel-Aviv University

This study's purpose was to compare DTI heterogeneity index with F18 fluorodeoxyglucose (FDG) standardized uptake value (SUVpeak) in liver metastases and in normal appearing liver tissue. The newly defined diffusion coefficient index (DCV) showed a stronger correlation to SUVpeak (r=0.714, p<0.001) than any other MR metrics evaluated. A threshold of DCV >0.05 and SUVpeak>2.88, correctly classified 28/35 (80%) and 32/35 (91.43%) liver metastases with AUC of 0.939 and 0.989, respectively. DCV, may provide quantitative data of tissue heterogeneity associated with liver metastases. In addition, DCV introduces a potential biomarker index as a quantitative discriminator of liver metastases.

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