Abstract #4506

Exploring flow effects on BOLD MRI with oxygen challenge in orthotopic lung tumor model

Heling Zhou¹, Zhongwei Zhang¹, Zhang Zhang², Jo Wagner¹, James Campbell¹, Shanrong Zhang³, Debabrata Saha², Masaya Takahashi³, and Ralph P Mason¹

¹Radiology, Univ Texas Southwestern Medical Center, Dallas, TX, United States, ²Radiation Oncology, Univ Texas Southwestern Medical Center, Dallas, TX, United States, ³Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States

Blood oxygen level dependent (BOLD) is sensitive to deoxyhemoglobin providing information on tumor oxygenation. However, the measurements are affected by blood flow. This study explored the extent of flow sensitivity by comparing the BOLD signal intensity and T₂* values with and without flow suppression using an orthotopic lung tumor model. T₂* appeared to be insensitive to flow for the tumor regions as observed in this preliminary study, while semi-quantitative ΔSI was strongly affected by flow and is a potential caveat. For well vascularized normal tissue (such as liver), flow suppression will be necessary for accurate measurements.

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