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Abstract #4508

Microenvironmental changes in prostatic tissues in relation to tumor growth in low risk prostate cancer

Hugh Harvey1, Veronica A Morgan1, Christopher Parker2, and Nandita M deSouza1

1CRUK Imaging Centre, The Institute of Cancer Research, Surrey, United Kingdom, 2Academic Urology Unit, The Royal Marsden Hospital NHS Foundation Trust, Sutton, United Kingdom

In 50 men with prostate cancer managed by active surveillance, changes in diffusion and perfusion within normal prostate and tumor were compared between those whose tumors did (“Growers”) or did not grow. 14% had >50% increase in tumor volume on MRI at 1-year. In these men, ADC of normal PZ was lower and more homogenous and remained unchanged over time; vascular metrics also remained stable. In TZ, no changes occurred in ADC or vascular metrics. In tumor, Kep increased with time in growers and ADC histogram metrics showed a left-shift indicating changes in tumor vascular and cellular microstructure with progression.

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