Abstract #4517

9.4 Tesla in vivo Quantitative Susceptibility Mapping (QSM) detects thalamic calcium influx associated with repeated mild traumatic brain injury (mTBI)

Ferdinand Schweser^1,2, Austin Poulsen³, Dhaval Shah¹, Nicola Bertolino¹, Marilena Preda^1,2, Jenni Kyyriäinen⁴, Asla Pitkänen⁴, Robert Zivadinov^1,2, and David J Poulsen³

¹Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, ²MRI Clinical and Translational Research Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, ³Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, ⁴Department of Neurobiology, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland

This work investigated if Quantitative Susceptibility Mapping (QSM) can detect thalamic Ca²⁺ influx associated with an alteration of the N-methyl-D-aspartate receptor in a rodent model of mild TBI (mTBI). We found significant concentrations of calcium after repeated mTBI, but not after single mTBI, suggesting that persistent calcium deposits represent a primary pathology of repeated injury.

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