Abstract #4518

Evolving Functional Connectivity in Rats following Mild Traumatic Brain Injury

Yu-Chieh Jill Kao^1,2, Chia-Feng Lu^1,2,3, Huai-Lu Chen^1,4, Ping-Huei Tsai^1,2,5, Fei-Ting Hsu^1,5, Hua-Shan Liu^1,6, Gilbert Aaron Lee^1,4, Paul Blakeley^1,4, Li-Chun Hsieh^1,5, Bao-Yu Hsieh⁷, and Cheng-Yu Chen^1,2,5

¹Translational Imaging Research Center, College of Medicine, Taipei Medical University, Taipei, Taiwan, ²Department of Radiology, School of Medicine, Taipei Medical University, Taipei, Taiwan, ³Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, ⁴Department of Medical Research, Taipei Medical University Hospital, Taipei, Taiwan, ⁵Department of Medical Imaging, Taipei Medical University Hospital, Taipei, Taiwan, ⁶School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan, ⁷Department of Biomedica, China Medical University, Taichung, Taiwan

Longitudinal rsfMRI showed the hyper-connectivity in the primary somatosensory cortex and DMN in the acute phase after experimental impact acceleration injury. This is the first demonstration of functional connectivity change with the preserved brain structure after mTBI in rats.

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