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Abstract #4519

Longitudinal Quantitative Susceptibility Changes after Mild Traumatic Brain Injury

Kevin Koch1, Robin Karr1, Brad Swearingen2, Ashley LaRoche2, Casey Anderson1, Timothy B Meier2, Michael McCrea2, and Andrew Nencka1

1Radiology, Medical College of Wisconsin, Milwaukee, WI, United States, 2Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States

We present findings of longitudinal quantitative susceptibility mapping measurements on a cohort of contact sport athletes that were imaged longitudinally (24 hour, 8 day, 6 month) following diagnosed sport-related concussions (N=22). A cohort (N=29) of contact sport controls was imaged longitudinally using the same protocol and allowed stability assessment stability of the measurement. In regions of high stability, changes in susceptibility after injury were assessed in comparison to an atlas constructed from the control data. Substantial susceptibility variations after injury were found in the deep brain nuclei, which recovered and stabilized in the following two measurement points.

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