Abstract #4520

Early NAA Reductions predict Neuropsychological Outcomes after Pediatric TBI

Barbara Holshouser¹, Jamie Pivonka-Jones², Joy Nichols², Udo Oyoyo¹, Karen Tong¹, and Stephen Ashwal³

¹Radiology, Loma Linda University, Loma Linda, CA, United States, ²Pediatric Psychology, Loma Linda University, Loma Linda, CA, United States, ³Pediatric Neurology, Loma Linda University, Loma Linda, CA, United States

The primary aim of this prospective study was to test the hypothesis that early 3D MR spectroscopic (MRSI) changes in discrete regions of the brain after TBI predict neuropsychologic outcomes 1 year after injury. MRSI was acquired at 3T in 68 pediatric mild to severe TBI subjects and 72 controls. Subacute NAA/Cr and NAA/Cho ratios were significantly reduced in TBI patients in all brain regions. A binary logistic regression analysis using combined subcortical NAA/Cr ratios alone predicted dichotomized neurologic outcome (93%), Full Scale IQ (78%), General Memory (82%) and General Attention (88%).

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