Meeting Banner
Abstract #4522

Mapping of endogenous glucose content on the detection of hypometabolic syndrome in experimental traumatic brain injury by glucoCEST

Tsang-Wei Tu1, Wael Ibrahim2, Neekita Jikaria3, Dima Hammoud 3, and Joseph Frank3

1Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, United States, 2National Library of Medicine, National Institutes of Health, 3Radiology and Imaging Sciences, National Institutes of Health

The current study investigated the feasibility of using glucoCEST technique, without delivering exogenous glucose as contrast agent, to measure the endogenous glucose content in brain by optimizing the saturation power and duration. The glucoCEST data were compared to the gold-standard 14C-2-deoxyglucose autoradiography for testing the sensitivity and specificity in the detection of hypometabolic syndrome in a rat model of diffuse traumatic brain injury (TBI). The glucoCEST showed comparable results to the 2DG-autoradiography showing glucose uptake largely decreased after TBI. Our findings suggest that glucoCEST could be a robust and reliable imaging modality capable of monitoring glucose metabolism non-invasively.

This abstract and the presentation materials are available to members only; a login is required.

Join Here