Abstract #4522

Mapping of endogenous glucose content on the detection of hypometabolic syndrome in experimental traumatic brain injury by glucoCEST

Tsang-Wei Tu¹, Wael Ibrahim², Neekita Jikaria³, Dima Hammoud ³, and Joseph Frank³

¹Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, United States, ²National Library of Medicine, National Institutes of Health, ³Radiology and Imaging Sciences, National Institutes of Health

The current study investigated the feasibility of using glucoCEST technique, without delivering exogenous glucose as contrast agent, to measure the endogenous glucose content in brain by optimizing the saturation power and duration. The glucoCEST data were compared to the gold-standard ¹⁴C-2-deoxyglucose autoradiography for testing the sensitivity and specificity in the detection of hypometabolic syndrome in a rat model of diffuse traumatic brain injury (TBI). The glucoCEST showed comparable results to the 2DG-autoradiography showing glucose uptake largely decreased after TBI. Our findings suggest that glucoCEST could be a robust and reliable imaging modality capable of monitoring glucose metabolism non-invasively.

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