Abstract #4523

Increased cerebral level of GABA- in the acute phase of children’s mild traumatic brain injury.

Petr Menshchikov^1,2, Tolibjon Akhadov², Olga Bozhko², and Natalia Semenova^1,2

¹Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russian Federation, ²Clinical and Research Institute of Urgent Pediatric Surgery and Trauma, Moscow, Russian Federation

There is not any information about [GABA] and [GABA]/[GLX] balance in human brain in acute phase of mTBI, but animal studies have shown alterations in concentrations of major inhibitory and excitatory neurotransmitters. [GABA-], [GABA+] and [GLX] were studied in vivo using MEGA-PRES pulse sequence in young patients (mean age - 16±2) with acute phase of mTBI. [GABA-]/[GLX] was significantly increased (p<0.05) in patients and [GABA-]/[tCr] had a trend for increase (p=0.09). This results correlates with animals experiments. [GABA+] didn't show any effects. Thus, [GABA-] MEGA-PRESS is more preferable for accurate [GABA] estimation.

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