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Abstract #4523

Increased cerebral level of GABA- in the acute phase of children’s mild traumatic brain injury.

Petr Menshchikov1,2, Tolibjon Akhadov2, Olga Bozhko2, and Natalia Semenova1,2

1Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russian Federation, 2Clinical and Research Institute of Urgent Pediatric Surgery and Trauma, Moscow, Russian Federation

There is not any information about [GABA] and [GABA]/[GLX] balance in human brain in acute phase of mTBI, but animal studies have shown alterations in concentrations of major inhibitory and excitatory neurotransmitters. [GABA-], [GABA+] and [GLX] were studied in vivo using MEGA-PRES pulse sequence in young patients (mean age - 16±2) with acute phase of mTBI. [GABA-]/[GLX] was significantly increased (p<0.05) in patients and [GABA-]/[tCr] had a trend for increase (p=0.09). This results correlates with animals experiments. [GABA+] didn't show any effects. Thus, [GABA-] MEGA-PRESS is more preferable for accurate [GABA] estimation.

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