Abstract #4544

Interleaved pulse sequence for calibrated BOLD based on MRI measurement of venous oxygen saturation

Erin K Englund¹, Maria A Fernandez-Seara², Hyunyeol Lee¹, Zachary B Rodgers¹, John A Detre³, and Felix W Wehrli¹

¹Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Department of Radiology, University of Navarra, Pamplona, Spain, ³Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States

An improved interleaved pulse sequence termed “OxBOLD” is presented for calibrated fMRI. OxBOLD measures ASL-based perfusion and BOLD signal changes with whole-brain coverage, in addition to global measures of blood flow and venous oxygen saturation by concatenating background-suppressed 3D-GRASE pCASL, phase contrast, 2D-multi-slice EPI, and dual-echo GRE sequences. The OxBOLD pulse sequence is combined with the Y_v-based calibration model to derive the calibration factor, M, which relates perfusion and BOLD signal changes to the cerebral metabolic rate of oxygen (CMRO₂). M-maps derived from OxBOLD have similar M values averaged over grey matter as compared to the traditional Davis calibration model.

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