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Abstract #4544

Interleaved pulse sequence for calibrated BOLD based on MRI measurement of venous oxygen saturation

Erin K Englund1, Maria A Fernandez-Seara2, Hyunyeol Lee1, Zachary B Rodgers1, John A Detre3, and Felix W Wehrli1

1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Department of Radiology, University of Navarra, Pamplona, Spain, 3Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States

An improved interleaved pulse sequence termed “OxBOLD” is presented for calibrated fMRI. OxBOLD measures ASL-based perfusion and BOLD signal changes with whole-brain coverage, in addition to global measures of blood flow and venous oxygen saturation by concatenating background-suppressed 3D-GRASE pCASL, phase contrast, 2D-multi-slice EPI, and dual-echo GRE sequences. The OxBOLD pulse sequence is combined with the Yv-based calibration model to derive the calibration factor, M, which relates perfusion and BOLD signal changes to the cerebral metabolic rate of oxygen (CMRO2). M-maps derived from OxBOLD have similar M values averaged over grey matter as compared to the traditional Davis calibration model.

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