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Abstract #4546

The first observation of 17O MRI in normal rats at 21.1 T

Victor D. Schepkin1, Andreas Neubauer2, Christian Schuch3, Tilo Glaeser3, Michael Kievel3, Steven L. Ranner1, William W. Brey1, Shannon Helsper1, and Lothar Schad2

1CIMAR, NHMFL/FSU, Tallahassee, FL, United States, 2University of Heidelberg, Mannheim, Germany, 3NUKEM Isotopes, Alzenau, Germany

The capability of 17O MRI in a rat head was evaluated at the high magnetic field of 21.1 T (NHMFL, Tallahassee). The results demonstrated that 17O MR relaxation times are dependent on the magnetic field strength which correlates with experimental observations for sodium. Well separated MR peaks of 17O water and 6-17O glucose provided the time courses of water distribution and glucose consumption in vivo. 3D 17O MRI is possible with a resolution of 1 mm3 in normal rats. 17O MRI is a promising tool for future tumor detection and evaluation of tumor glucose consumption rates.

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