Meeting Banner
Abstract #4560

In vivo measurement of water exchange at the human blood-cerebrospinal fluid barrier

Valerie C Anderson1, Xin Li1, Aaron Doud1, Ian J Tagge1, Eric M Baker1, Joseph F Quinn2, Jeffrey A Kaye2, and William D Rooney1

1Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, 2Dept. of Neurology, Oregon Health & Science University, Portland, OR, United States

Epithelial cells of the choroid plexus contain the blood-CSF barrier and play a pivotal role in brain water homeostasis. Here, DCE-MRI was used to investigate choroid plexus water exchange in 25 older individuals. A marked non-linearity of blood and tissue R1 values was observed, indicating that water exchange departs the fast exchange limit at clinical blood contrast agent levels. Using a two-site model that explicitly incorporates water exchange between intra- and extraventricular compartments, a mean rate constant for ventricular water efflux, kio, of 0.26 ± 0.13 s-1 was obtained. Significant associations of kio with age and cognitive status were found.

This abstract and the presentation materials are available to members only; a login is required.

Join Here