Abstract #4560

In vivo measurement of water exchange at the human blood-cerebrospinal fluid barrier

Valerie C Anderson¹, Xin Li¹, Aaron Doud¹, Ian J Tagge¹, Eric M Baker¹, Joseph F Quinn², Jeffrey A Kaye², and William D Rooney¹

¹Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, ²Dept. of Neurology, Oregon Health & Science University, Portland, OR, United States

Epithelial cells of the choroid plexus contain the blood-CSF barrier and play a pivotal role in brain water homeostasis. Here, DCE-MRI was used to investigate choroid plexus water exchange in 25 older individuals. A marked non-linearity of blood and tissue R₁ values was observed, indicating that water exchange departs the fast exchange limit at clinical blood contrast agent levels. Using a two-site model that explicitly incorporates water exchange between intra- and extraventricular compartments, a mean rate constant for ventricular water efflux, k_io, of 0.26 ± 0.13 s^-1 was obtained. Significant associations of k_io with age and cognitive status were found.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.