Hyperintensity in the dentate nucleus (DN) on unenhanced T1-weighted images was associated with previous administration of gadodiamide but not gadoxetic acid. There were no significant differences in DN-to-pons ratio between patients who received five or more administrations of gadoxetic acid and those without gadolinium-based contrast agent administration or chronic liver disease. Hyperintensity in the dentate nucleus on unenhanced T1-weighted images is not associated with up to fifteen previous administrations of gadoxetic acid. Therefore, gadolinium deposition in the brain might be difficult despite a history of repeated gadoxetic acid administration.
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