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Abstract #4562

Evaluation of hemodynamic impairments in healthy elderly participants and patients with high-grade unilateral carotid artery stenosis

Stephan Kaczmarz1, Jens Göttler1, Vanessa Griese1, Jan Petr2, Kim van de Ven3, Michael Helle4, Hendrick Kooijman5, Anne Kluge6, Dimitrios C. Karampinos7, Claus Zimmer1, Christian Sorg1,8, and Christine Preibisch1,8,9

1Department of Neuroradiology, Technical University of Munich, Munich, Germany, 2PET center, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany, 3Philips Healthcare, Best, Netherlands, 4Philips Research, Hamburg, Germany, 5Philips Healthcare, Hamburg, Germany, 6Department of Radiation Oncology and Radiotherapy, Charité Berlin, Berlin, Germany, 7Department of Radiology, Technical University of Munich, Munich, Germany, 8TUM Neuroimaging Center, Technical University of Munich, Munich, Germany, 9Clinic for Neurology, Technical University of Munich, Munich, Germany

Internal carotid-artery stenosis (ICAS) causes complex and not yet well understood physiological impairments. We present preliminary data from an ongoing clinical study in ICAS patients and healthy, age-matched participants. The major aims were to evaluate the reliability of a multimodal MRI-protocol and investigate physiological changes. For ICAS patients, regionally impaired vascular-reactivity as well as hypo-perfusion were found. In accordance with literature, we did not find ICAS-induced changes in oxygen extraction on group level. The presented preliminary results thus imply successful application of multimodal MRI methods and are highly promising with respect to gaining a deeper insight into ICAS-related physiological changes.

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