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Abstract #4565

Associations between white matter lesions, age, and 4D flow MRI hemodynamics in 69 patients with Sickle Cell Disease

Lena Vaclavu1, Zelonna Baldew1, Sanna Gevers1, Veronica van der Land2, Henri JMM Mutsaerts3, Karin Fijnvandraat2, John C Wood4, Charles BLM Majoie1, Ed T vanBavel5, Bart J Biemond6, Aart J Nederveen1, and Pim van Ooij1

1Radiology, Academic Medical Center, Amsterdam, Netherlands, 2Pediatric Hematology, Emma Children's Hospital, Academic Medical Center, Amsterdam, Netherlands, 3Sunnybrook Research Institute, Toronto, Canada, 4Cardiology, Children's Hospital Los Angeles, Los Angeles, CA, United States, 5Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, Netherlands, 6Internal Medicine, Hematology, Academic Medical Center, Amsterdam, Netherlands

Hemodynamic parameters such as wall shear stress(WSS) may be adversely affected in Sickle Cell Disease(SCD). Vaso-occlusion is a common complication leading to ischemic organ damage. We investigated how impaired hemodynamics (velocity, WSS, flow and lumen area) relate to ischemic white matter lesions(WMLs). Our aim was to quantify age-related changes in hemodynamics and to investigate their relationship with WMLs. 14 controls and 69 patients underwent 4D-flow MRI. We assessed intracranial velocity, WSS, flow and lumen area in the circle of Willis. We show that 4D-flow parameters are decreased in patients with WMLs, but age is an important factor in this relationship.

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