Abstract #4565

Associations between white matter lesions, age, and 4D flow MRI hemodynamics in 69 patients with Sickle Cell Disease

Lena Vaclavu¹, Zelonna Baldew¹, Sanna Gevers¹, Veronica van der Land², Henri JMM Mutsaerts³, Karin Fijnvandraat², John C Wood⁴, Charles BLM Majoie¹, Ed T vanBavel⁵, Bart J Biemond⁶, Aart J Nederveen¹, and Pim van Ooij¹

¹Radiology, Academic Medical Center, Amsterdam, Netherlands, ²Pediatric Hematology, Emma Children's Hospital, Academic Medical Center, Amsterdam, Netherlands, ³Sunnybrook Research Institute, Toronto, Canada, ⁴Cardiology, Children's Hospital Los Angeles, Los Angeles, CA, United States, ⁵Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, Netherlands, ⁶Internal Medicine, Hematology, Academic Medical Center, Amsterdam, Netherlands

Hemodynamic parameters such as wall shear stress(WSS) may be adversely affected in Sickle Cell Disease(SCD). Vaso-occlusion is a common complication leading to ischemic organ damage. We investigated how impaired hemodynamics (velocity, WSS, flow and lumen area) relate to ischemic white matter lesions(WMLs). Our aim was to quantify age-related changes in hemodynamics and to investigate their relationship with WMLs. 14 controls and 69 patients underwent 4D-flow MRI. We assessed intracranial velocity, WSS, flow and lumen area in the circle of Willis. We show that 4D-flow parameters are decreased in patients with WMLs, but age is an important factor in this relationship.

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