Hemodynamic parameters such as wall shear stress(WSS) may be adversely affected in Sickle Cell Disease(SCD). Vaso-occlusion is a common complication leading to ischemic organ damage. We investigated how impaired hemodynamics (velocity, WSS, flow and lumen area) relate to ischemic white matter lesions(WMLs). Our aim was to quantify age-related changes in hemodynamics and to investigate their relationship with WMLs. 14 controls and 69 patients underwent 4D-flow MRI. We assessed intracranial velocity, WSS, flow and lumen area in the circle of Willis. We show that 4D-flow parameters are decreased in patients with WMLs, but age is an important factor in this relationship.