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Abstract #4564

Longitudinal metabolic evolution of rat cortex upon global ischemia: an ultra-short echo time 1H MRS study

Mario G Lepore1 and Hongxia Lei1,2

1Biomedical Imaging Research Center, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 2University of Geneva, Geneva, Switzerland

Stroke is a leading cause for disability. Metabolic evolution of transient ischemia attack might shed insights for diagnosis and prognosis. We aimed to 1H MRS study metabolic evolution of cortex before, during and immediately after 15-min complete global ischemia. Combination of MR angiography (MRA) and 1H MRS allows execution of vascular occlusion models directly in the magnet as well as proper identification and characterization of complete stroke.

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