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Abstract #4567

Comparison of the Arterial transit artifact of pcASL between stroke patients with cerebral artery stenosis and normal controls

Le He1, Shuo Chen1, Zhensen Chen1, Lixia Yang2, Xihai Zhao1, Chun Yuan1,3, and Huijun Chen1

1Center for BioMedical Imaging Research,Tsinghua, Beijing, People's Republic of China, 2Department of Image Center, Shanghai Xuhui Center Hospital, Shanghai, People's Republic of China, 3Department of radiology, University of Washington, Seattle, WA, United States

Cerebral blood flow (CBF) reduction below a certain threshold is a main cause leading to cerebral ischemia . Arterial Spin Labeling (ASL) is a noncontrast MRI perfusion technique that can quantify CBF. Although ATA may be problematic for CBF quantification, there are evidences suggest that ATA may be a useful imaging biomarker to represent collateral flow and indicate better outcomes , this study aims to investigate the difference of ATA prevalence between stroke patients with cerebral artery stenosis and healthy volunteers. It was found that the stroke patients have more brain regions with long arterial transit time compared with healthy volunteers using a manual review method to estimate the overall CBF of subject while allowing ATA detection, suggesting ATA could be a potential imaging biomarker.

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