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Abstract #4572

Slower Information Processing Speed is related to White-Matter Integrity in Sickle Cell Disease

Hanne Stotesbury1, Fenella J Kirkham1, Chris A Clark1, and Jamie M Kawadler 1

1Developmental Neurosciences, UCL Great Ormond Street Institute of Child Health, London, United Kingdom

Sickle cell disease (SCD) is associated with stroke1 and slower processing2. Slower processing in the absence of stroke may be related to hypoxic-ischaemic white-matter (WM) injury3. Cognitive assessments and tract-based spatial statistics analyses using diffusion tensor imaging (DTI), were conducted in 84 patients with SCD, stratified by degree of hypoxic-anaemic exposure. Processing speed indices (PSI) were related to WM integrity, and there were differences in PSI and WM integrity as a function of daytime oxygen-desaturation, but not SCI. The results provide links between oxygen desaturation, PSI, and WM integrity, and may indicate amelioration of function by interventions that reduce hypoxic exposure.

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