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Abstract #4571

4D Flow assessment of ophthalmic artery flow in patients with atherosclerotic internal carotid artery stenotic disease

Tetsuro Sekine1, Ryo Takagi1, Yasuo Amano1,2, Yasuo Murai3, Yoshimitsu Fukushima1, Erika Orita1, Takahiro Andoh1, Yoshio Matsumura3, and Shin-ichiro Kumita1

1Radiology, Nippon Medical School, Tokyo, Japan, 2Radiology, Nihon University School of Medicine, Tokyo, Japan, 3Neurosurgery, Nippon Medical School, Tokyo, Japan

We performed 4D Flow MRI assessment of the ophthalmic artery (OphA) flow in patients with internal carotid artery stenosis (ICS). Twenty-one consecutive patients with unilateral ICS were recruited. 4D Flow MRI and acetazolamide-stress brain perfusion SPECT were performed. The flow direction on the affected-side OphA was categorized into native flow and non-native flow based on 4D Flow MRI. In the affected-side MCA territory, the ratio of rest cerebral blood flow to normal control (RCBFMCA) and cerebral vascular reserve (CVRMCA) were calculated from SPECT dataset. Eleven patients had native OphA flow and the remaining 10 had non-native OphA flow. RCBFMCA and CVRMCA were significantly lower in non-native flow group (84.9±18.9% vs. 69.8±7.3%, p<0.05; 36.4±20.6% vs. 17.0±15.0%, p<0.05). Four patients in the non-native flow group and none in the native flow group were confirmed as high-risk (Sensitivity/Specificity, 1.00/0.65). The 6 min-standard 4D Flow MRI assessment of OphA in patients with ICS can predict intracranial hemodynamic impairment.

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