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Abstract #4570

Cerebral perfusion characteristics show differences in younger vs. older children with sickle cell anaemia: results from a multiple inflow-time arterial spin labelling study

Jamie M Kawadler1, Patrick W Hales1, Fenella J Kirkham1, and Chris A Clark1

1Developmental Neurosciences, UCL Great Ormond Street Institute of Child Health, London, United Kingdom

Sickle cell disease (SCD) is associated with chronic anaemia and oxygen desaturation, which elevates cerebral blood flow (CBF) and increases risk of stroke. Cerebral haemodynamics are abnormal and techniques for assessing CBF using a single inflow-time may not be sufficient. This study investigated haemodynamic parameters from a multi-inflow-time acquisition in younger and older children with SCD and healthy controls. CBF was elevated globally in both groups of patients, but in older children, patients had significantly shorter bolus arrival time. This may indicate increasing disparity between patients and controls with age and may be related to longer standing burden of disease.

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