Sickle cell disease (SCD) is associated with chronic anaemia and oxygen desaturation, which elevates cerebral blood flow (CBF) and increases risk of stroke. Cerebral haemodynamics are abnormal and techniques for assessing CBF using a single inflow-time may not be sufficient. This study investigated haemodynamic parameters from a multi-inflow-time acquisition in younger and older children with SCD and healthy controls. CBF was elevated globally in both groups of patients, but in older children, patients had significantly shorter bolus arrival time. This may indicate increasing disparity between patients and controls with age and may be related to longer standing burden of disease.
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