Abstract #4569

Prevalence and Clinical Relevance of Intraplaque Haemorrhage in Stenotic and Non-stenotic Basilar Artery Intracranial Atherosclerotic Plaque

Chengcheng Zhu¹, Xia Tian², Andrew Degnan³, Zhongzhao Teng⁴, Jianping Lu², David Saloner¹, and Qi Liu²

¹Radiology, University of California, San Francisco, San Francisco, CA, United States, ²Radiology, Changhai Hospital, Shanghai, People's Republic of China, ³Radiology, University of Pittsburgh, PA, United States, ⁴Radiology, University of Cambridge, Cambridge, United Kingdom

Intraplaque hemorrhage (IPH) in intracranial arteries is a possible marker of increased stroke risk. While previous studies focused on stenotic arteries, non-stenotic arteries also cause fatal stroke. We studied 100 patients using high-resolution MRI and found IPH was prevalent (>20%) in both stenotic and non-stenotic basilar arteries, and was a strong predictor of symptoms with an odd ratios of 15.4. IPH has a very high specificity (97.1%) to predict symptoms. Specifically, IPH may be useful in selecting high risk stroke patients with clinically non-significant stenosis, who may benefit from more aggressive treatment.

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