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Abstract #4569

Prevalence and Clinical Relevance of Intraplaque Haemorrhage in Stenotic and Non-stenotic Basilar Artery Intracranial Atherosclerotic Plaque

Chengcheng Zhu1, Xia Tian2, Andrew Degnan3, Zhongzhao Teng4, Jianping Lu2, David Saloner1, and Qi Liu2

1Radiology, University of California, San Francisco, San Francisco, CA, United States, 2Radiology, Changhai Hospital, Shanghai, People's Republic of China, 3Radiology, University of Pittsburgh, PA, United States, 4Radiology, University of Cambridge, Cambridge, United Kingdom

Intraplaque hemorrhage (IPH) in intracranial arteries is a possible marker of increased stroke risk. While previous studies focused on stenotic arteries, non-stenotic arteries also cause fatal stroke. We studied 100 patients using high-resolution MRI and found IPH was prevalent (>20%) in both stenotic and non-stenotic basilar arteries, and was a strong predictor of symptoms with an odd ratios of 15.4. IPH has a very high specificity (97.1%) to predict symptoms. Specifically, IPH may be useful in selecting high risk stroke patients with clinically non-significant stenosis, who may benefit from more aggressive treatment.

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