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Abstract #4580

Sickle hemoglobin vs. normal hemoglobin: Any changes in susceptibility?

Cihat Eldeniz1, Michael Binkley2, Dustin K. Ragan3, Melanie Fields3, Kristin Guilliams3, Liam Comiskey3, Yasheng Chen3, Andria L Ford3, Jin-Moo Lee3, and Hongyu An1

1Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, United States, 2Washington University in St. Louis, St. Louis, MO, United States, 3Washington University in St. Louis

Alterations in cerebral oxygenation may be helpful as an imaging biomarker to predict stroke risk in sickle cell disease (SCD). Such measurement requires the knowledge of susceptibility properties of sickle hemoglobin, HbS. In this study, we aimed at measuring volume susceptibility difference between fully-oxygenated and full-deoxygenated blood, Δχo, of HbS and HbA. The measured Δχo of HbA is consistent with literature reported range, and Δχo of HbS is greater than that of HbA. However, this difference does not reach statistical significance.

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