Alterations in cerebral oxygenation may be helpful as an imaging biomarker to predict stroke risk in sickle cell disease (SCD). Such measurement requires the knowledge of susceptibility properties of sickle hemoglobin, HbS. In this study, we aimed at measuring volume susceptibility difference between fully-oxygenated and full-deoxygenated blood, Δχo, of HbS and HbA. The measured Δχo of HbA is consistent with literature reported range, and Δχo of HbS is greater than that of HbA. However, this difference does not reach statistical significance.