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Abstract #4581

How does acute hypertensive crisis affect brain volume? A structural MRI study

Arzu Ceylan Has1, Mehmet Yasir Pektezel2, Mehmet Akif Topcuoglu2, Rahsan Gocmen3, Bulent Erbil4, Nalan Metin Aksu4, Ethem Murat Arsava2, and Kader K. Oguz3

1National Magnetic Resonance Research Center (UMRAM), Ankara, Turkey, 2Department of Neurology, Faculty of Medicine, Hacettepe University, Ankara, Turkey, 3Department of Radiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey, 4Department of Emergency Room, Faculty of Medicine, Hacettepe University, Ankara, Turkey

Acute elevations in systemic blood pressure can lead to a wide spectrum of central nervous system manifestations, including catastrophic scenarios like intracerebral hemorrhage. We hypothesized that brain swelling occurs in hypertensive crisis patients, assessed by structural MRI. We prospectively collected MRI data from a consecutive series of patients admitted to the emergency department with a diagnosis of hypertensive urgency but no neurologic symptoms. A second MRI was obtained at 3-months follow-up of blood pressure normalization. MRI analysis revealed reductions in cortical and sub-cortical gray matter after normalization of blood pressure.

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