The underlying pathophysiological mechanisms of paroxysmal kinesigenic dyskinesia are still not fully understood. The aim of this study was to investigate the patterns of resting-sate functional connectivity of thalamus in patients with paroxysmal kinesigenic dyskinesia. Our novel findings of abnormal resting-sate functional connectivity from thalamus to precentral gyrus and medial frontal gyrus provided direct evidence that the basal ganglia-thalamo-cortical circuit may play an important role in the pathogenesis of paroxysmal kinesigenic dyskinesia.
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