Abstract #4586

Abnormal resting-sate functional connectivity of thalamus in patients with paroxysmal kinesigenic dyskinesia

Guangxiang Chen¹, Du Lei¹, Jiechuan Ren², Xiaoqi Huang¹, Dong Zhou², and Qiyong Gong¹

¹Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu, People's Republic of China, ²Department of Neurology, West China Hospital, Sichuan University, Chengdu, People's Republic of China

The underlying pathophysiological mechanisms of paroxysmal kinesigenic dyskinesia are still not fully understood. The aim of this study was to investigate the patterns of resting-sate functional connectivity of thalamus in patients with paroxysmal kinesigenic dyskinesia. Our novel findings of abnormal resting-sate functional connectivity from thalamus to precentral gyrus and medial frontal gyrus provided direct evidence that the basal ganglia-thalamo-cortical circuit may play an important role in the pathogenesis of paroxysmal kinesigenic dyskinesia.

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