Abstract #4587

Associative areas and cerebellum show non-linear modulation of fMRI signal when using the non-dominant hand

Adnan A.S. Alahmadi^1,2, Rebecca S. Samson¹, Matteo Pardini^1,3, Egidio D'Angelo^4,5, Karl J. Friston⁶, Ahmed T. Toosy¹, and Claudia AM Gandini Wheeler-Kingshott^1,4,7

¹UCL Institute of Neurology, Queen Square MS Centre, University College London, London, United Kingdom, ²Department of Diagnostic Radiology, Faculty of Applied Medical Science, KAU, Jeddah, Saudi Arabia, ³Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics and Maternal and Child Health, University of Genoa, Genoa, Italy, ⁴Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, ⁵Brain Connectivity Centre, C. Mondino National Neurological Institute, Pavia, Italy, ⁶Wellcome Centre for Imaging Neuroscience, University College London, London, United Kingdom, ⁷Brain MRI 3T Mondino Research Center, C. Mondino National Neurological Institute, Pavia, Italy

We investigated linear and non-linear BOLD-grip force (GF) relationships in the brain using dominant (DH) and non-dominant hands (NDH). The NDH revealed widespread brain activations compared to DH, irrespective of GF. Looking at the BOLD-GF effects, both hands showed increased activations with increased GF within the contralateral M1 and ipsilateral anterior cerebellum. Non-linear BOLD-GF relationships (up to 4^th order) were found, typically in posterior M1, premotor, sensory, parietal, and cerebellar areas. Finally, the consistent bilateral involvement of the cerebral and cerebellar areas suggests their involvement in error tracking or in synkinetic processes between DH and NDH.

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