Several neuroimaging studies demonstrated that solvent-exposed subjects showed significantly poor performance on the working memory task than did controls [1,2]. However, no investigations have examined how solvent-exposed subjects are influenced by the cognitive load of a working memory task. Therefore, we performed N-back tasks with different cognitive demands using fMRI to investigate the neural basis for possible association between working memory load and memory deficit in the subjects with neurotoxicant solvent exposure. We found a positive correlation between response time of the 1-back task and percent BOLD signal changes in the left inferior parietal cortex, but a positive correlation was not founded of the 2-back task.
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