Abstract #4610

Differentiation of Intracerebral Hemorrhage from Ischemic Stroke at Early Stage Using a Novel Scheme of Length and Offset VARied Saturation (LOVARS) MRI

Yan Bai^1,2, Meiyun Wang¹, Yue Li³, Xiaowei He⁴, Xiaoyue Ma¹, Panli Zuo⁵, Yucheng Li¹, and Xiaolei Song²

¹Henan Provincial People’s Hospital, Zhengzhou, People's Republic of China, ²The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³AnatomyWorks LLC, Baltimore, MD, United States, ⁴Northwest University, Xi'an, People's Republic of China, ⁵Siemens Healthcare China, Beijing, People's Republic of China

This study investigated the diagnostic capability of a novel scheme of Length and Offset VARied Saturation (LOVARS) CEST method, for detecting and differentiating intracerebral hemorrhage from ischemic stroke at early stage. With the saturation offsets of 2 ppm and -3.5 ppm, the new LOVARS real image is able to separate ischemic lesion from hemorrhagic lesion by the opposite signal appearances for all patients enrolled. i.e. the former is hypointensity while the latter is hyperintensity. Our results revealed that the LOVARS real signals are significantly higher in hemorrhage than in ischemic stroke, which may serve as an imaging marker.

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