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Abstract #4610

Differentiation of Intracerebral Hemorrhage from Ischemic Stroke at Early Stage Using a Novel Scheme of Length and Offset VARied Saturation (LOVARS) MRI

Yan Bai1,2, Meiyun Wang1, Yue Li3, Xiaowei He4, Xiaoyue Ma1, Panli Zuo5, Yucheng Li1, and Xiaolei Song2

1Henan Provincial People’s Hospital, Zhengzhou, People's Republic of China, 2The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3AnatomyWorks LLC, Baltimore, MD, United States, 4Northwest University, Xi'an, People's Republic of China, 5Siemens Healthcare China, Beijing, People's Republic of China

This study investigated the diagnostic capability of a novel scheme of Length and Offset VARied Saturation (LOVARS) CEST method, for detecting and differentiating intracerebral hemorrhage from ischemic stroke at early stage. With the saturation offsets of 2 ppm and -3.5 ppm, the new LOVARS real image is able to separate ischemic lesion from hemorrhagic lesion by the opposite signal appearances for all patients enrolled. i.e. the former is hypointensity while the latter is hyperintensity. Our results revealed that the LOVARS real signals are significantly higher in hemorrhage than in ischemic stroke, which may serve as an imaging marker.

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