Abstract #4611

Measurement of mean transit time changes in response to Acetozalomide challenge in patients with cerebral steno-occlusive disease: a study using dynamic susceptibility contrast MR perfusion imaging.

Kyle Pate¹, Junjie Wu¹, Seena Dehkharghani², Fadi Nahab¹, Jason Allen, and Deqiang Qiu¹

¹Emory University, Atlanta, GA, United States, ²New York University

In this paper, 9 patients with chronic cerebrovascular disease underwent a two day MR perfusion study with a Diamox challenge in order to quantify cerebrovascular reserve with a focus on MTT and Tmax parameters. Parametric maps were generated and used to compare regional differences in four perfusion parameters between the left and right hemispheres, MCA and ACA vascular territories, and the cerebellum. This approach demonstrated an unexpected increase in MTT and Tmax augmentation in the anterior circulation over augmentation in the cerebellum.

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