Amyotrophic lateral sclerosis (ALS), a progressive motor neuron disease, is characterized by severe cervical spinal cord damage caused by degeneration of the corticospinal tracts and loss of lower motor neurons. Although MR imaging of spinal cord is challenging, the ubiquity and non-invasive nature of MRI has supported its continued development and a leading role in ALS biomarker discovery. In this study, we investigated the feasibility of exploiting high b-value diffusion MRI to evaluate alterations of the spinal cord in a mouse model of ALS.
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