Abstract #4626

FEAST based Arterial Transit Time Measurement using Pseudo Continuous Arterial Spin Labeling in Patients with Sickle Cell Disease

Yihao Xia¹, Yaqiong Chai^2,3, Adam M Bush², Natasha Lepore³, Thomas Coates⁴, and John Wood^3,5

¹Department of Electrical Engineering, University of Southern California, Los Angeles, CA, United States, ²Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States, ³Radiology, Children's Hospital of Los Angeles, Los Angels, CA, United States, ⁴Section of Hematology, Children's Hospital of Los Angeles, Los Angels, CA, United States, ⁵Division of Cardiology, Children's Hospital of Los Angeles, Los Angels, CA, United States

Sickle cell disease (SCD) is a genetic blood disorder with a high prevalence of cerebral vasculopathy and stroke. Arterial Transit Time (ATT) refers to the time it takes blood to flow from the labeling plane, to the vascular imaging compartment and reflects cerebrovascular impairment in SCD. We used pseudo continuous arterial spin labeling to measure ATT with flow encoding arterial spin tagging technique in patients with SCD and ethnicity matched, healthy controls. Our findings demonstrated sensitivity of ATT to vasculopathy.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.