Abstract #4627

Electric properties tomography in a rodent model of ischemic stroke: Results of a combined ex-vivo and in-vivo pilot study.

Ulf Jensen-Kondering¹, Ruwen Böhm², Liang Shu¹, Olav Jansen¹, and Ulrich Katscher³

¹Department of Radiology and Neuroradiology, UKSH, Kiel, Germany, ²Department of Experimental and Clinical Pharmacology, UKSH, Kiel, Germany, ³Research Laboratories, Philips GmbH Innovative Technologies, Hamburg, Germany

Electric properties tomography (EPT) is a new contrast in MRI which delivers information on tissue electrical conductivity. Up to now, it has been mostly used for tumor mapping. Ischemic cerebral stroke is another promising application. Seven male Wistar rats were used in this study. Five culled animals from another stroke study, three of which were subjected to MCAO and two live animals which were also subjected to MCAO were examined. Healthy cortical grey matter, white matter and cerebrospinal fluid could be well differentiated Conductivity was altered within the infarct. EPT is feasible in a rodent model of stroke.

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