Abstract #4628

Measure Cerebral Microstructure Changes in Brain Small Vessel Disease Using Diffusion Kurtosis Imaging

Wenjing Lan¹, Shuang Xu¹, Yang Liu¹, Kaining Shi², and Lizhi Xie³

¹The First Hospital of Jilin University, Changchun, People's Republic of China, ²Philips Healthcare (China), Beijing, People's Republic of China, ³GE Healthcare, MR Research China, Beijing, People's Republic of China

Diffusion tensor imaging (DTI) has been the most commonly used modality among diffusion MRI methods in the studies of ageing and development in the current study, we investigated diffusional modifications arising from brain small vessel disease, as compared with age and educational level matched healthy controls. Diffusion kurtosis imaging (DKI) was applied throughout the study, which is a recent novel extension of DTI to provide additional metrics quantifying non-Gaussianity of water diffusion in brain tissues.

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