The purpose of this study is to investigate the feasibility of reducing the scan time while maintaining the sensitivity to BBB permeability changes. We propose a new model, extended Patlak model (EPL), where plasma flow is added to the Patlak model. The numerical simulation and in vivo mouse data in this study suggest that the proposed EPL model can be used to measure BBB permeability change with DCE-MRI scan time of 10 min or less.
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