Meeting Banner
Abstract #4632

Measurement of Blood-Brain Barrier Permeability using Dynamic Contrast-Enhanced Magnetic Resonance Imaging with Reduced Scan Time

Jonghyun Bae1, Jin Zhang1, Orlando Aristizabal1, Willis Chen1, Youssef Zaim Wadghiri1, Yulin Ge1, and Sungheon Gene Kim1

1Center for Advanced Imaging Innovation and Research, Radiology, New York University School of Medicine, New York, NY, United States

The purpose of this study is to investigate the feasibility of reducing the scan time while maintaining the sensitivity to BBB permeability changes. We propose a new model, extended Patlak model (EPL), where plasma flow is added to the Patlak model. The numerical simulation and in vivo mouse data in this study suggest that the proposed EPL model can be used to measure BBB permeability change with DCE-MRI scan time of 10 min or less.

This abstract and the presentation materials are available to members only; a login is required.

Join Here