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Abstract #4636

MR Imaging & Spectroscopy in a Non-Human Primate Model of Ebola Makona Aerosol Exposure

Margaret R Lentz1, Anna N Honko1, Jordan K Bohannon1, Matthew G Lackemeyer1, Jeffrey M Solomon2, Louis M Huzella1, Gene G Olinger1, Lisa E Hensley1, and Peter B Jahrling1,3

1NIAID/Integrated Research Facility, National Institutes of Health, Frederick, MD, United States, 2Clinical Research Directorate & Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Frederick, MD, United States, 3NIAID, Emerging Viral Pathogens Section, National Institutes of Health, Frederick, MD, United States

The purpose of this study was to use MRI and magnetic resonance spectroscopy (MRS) to determine if structural or metabolic alterations occur in the brain of rhesus macaques exposed to Ebola virus via inhalation of aerosolized small particles. Unlike intramuscular inoculation with Ebola virus, small-particle aerosol exposure of macaques did not result in uniform changes in brain volume or vascular alterations 8-9 days after exposure. However, most animals had reductions in N-acetyl aspartate and increases in choline levels, indicating spectroscopy may be useful in identifying early alterations in brain metabolism due to Ebola virus disease.

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