Abstract #4635

Sleep-Disordered Breathing Severity in Elderly is Associated with Decreased GABA in the Dorsolateral Prefrontal Cortex: A J-edited 1H MRS and Polysomnography Study

Ana C Pereira¹, Xiangling Mao², Caroline S Jiang³, Guoxin Kang², SAra Milrad⁴, Bruce S McEwen³, Ana C Krieger⁴, and Dikoma C. Shungu⁵

¹Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY, United States, ²Radiology, Weill Cornell Medicine, ³Laboratory of Neuroendocrinology, The Rockefeller University, ⁴Medicine, Neurology and Neuroscience, Weill Cornell Medicine, ⁵Radiology, Weill Cornell Medicine, New York, NY, United States

Sleep-disordered breathing (SDB) is a disorder characterized by repeated episodes of hypopnea and apnea during sleep that lead to sleep fragmentation and intermittent hypoxia. A leading model of model of SDB that posits GABAergic and glutamatergic dysregulations that lead to hyperexcitability and neuronal damage, which this study aimed to investigate using J-edited MRS and polysomnography. The main results were a robust DLPFC GABA decrease and associations between GABA and hypoxia as well as disease severity. The state of hyperexcitability observed in SDB is interpreted as likely the result of disinhibition (GABA) that might lead to excitotoxicity and neuronal damage.

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