Sleep-disordered breathing (SDB) is a disorder characterized by repeated episodes of hypopnea and apnea during sleep that lead to sleep fragmentation and intermittent hypoxia. A leading model of model of SDB that posits GABAergic and glutamatergic dysregulations that lead to hyperexcitability and neuronal damage, which this study aimed to investigate using J-edited MRS and polysomnography. The main results were a robust DLPFC GABA decrease and associations between GABA and hypoxia as well as disease severity. The state of hyperexcitability observed in SDB is interpreted as likely the result of disinhibition (GABA) that might lead to excitotoxicity and neuronal damage.
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