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Abstract #4638

Individual mapping of neuronal damage in early relapsing-remitting MS using [11C]Flumazenil PET

Emilie Poirion1,2, Benedetta Bodini1, Marco Battaglini3, Theodore Soulier1, Léorah Freeman1, Daniel Lorenzo-Garcia1, Géraldine Bera1, Michel Bottlaender4, and Bruno Stankoff1

1Institut du Cerveau et de la Moelle Epinière/CNRS UMR 7225/INSERM 1127/UPMC UM75, Paris, France, Paris, France, 2CEA, DRF, I2BM, Neurospin, UNIRS, Paris, France, 3rtement of medecine, Surgery and Neuroscience, University of Siena, Siena, Italy, Italy, 4CEA, DRF, I2BM, Neurospin, UNIACT, Paris, France

We explored the neuronal component of grey matter damage in the earliest phase of multiple sclerosis (MS) with [11C]Flumazenil positron emission tomography (PET). Using a novel post-processing approach based on the generation of individual maps of neuronal pathology, we found a significant neuronal damage in the cortical lesions of patients with MS which preceded the occurrence of cortical atrophy, and correlated with white matter lesion load. These results suggest that cortical demyelination, together with retrograde degeneration of transected axons within white matter lesions, are among the key pathogenic contributors to neuronal cortical damage at the earliest stage of the disease.

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