1H MR Spectroscopy yields metabolic information and has proved to be a useful addition to structural imaging in neurological diseases. We applied short-TE Spectroscopic Imaging combined with linear modelling with respect to brain tissue type in a homogeneous cohort of 42 patients with Secondary Progressive Multiple Sclerosis. Metabolite levels were significantly different in lesions compared with normal appearing tissues, suggesting axonal damage (reduced NAA) and increased glial activity (increased myo-inositol) yet relatively stable lesions (reduced Glx).
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