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Abstract #4645

Dependence of degree of motor impairment on the association between motor performance and sensorimotor GABA level in relapsing remitting multiple sclerosis

Pallab Bhattacharyya1, Micheal Phillips1, Lael Stone2, and Mark Lowe1

1Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, 2Neurological Institute, Cleveland Clinic, Cleveland, OH, United States

Gamma aminobutyric acid (GABA), a major inhibitory neurotransmitter, has been implicated as a metabolic marker of multiple sclerosis (MS). Previously it has been shown that sensorimotor cortex GABA level is higher in relapsing remitting MS (RRMS) patients with poorer motor performance. In this study, the association between cortical GABA level and motor performance, as measured by 9-hole peg test score, has been studied for groups of patients with RRMS with different degrees of motor impairment. The results suggest that cortical GABA has more involvement in motor performance in early stage of RRMS or in less impaired patients.

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