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Abstract #4654

Implications of Obstructive Sleep Apnea on Global Cerebral Metabolic Rate of Oxygen

Ana E Rodríguez-Soto1, Yulin Chang1, Wen Cao1, Zachary B Rodgers1, John A Detre2, Erin K Englund1, Sarah Leinwand3, Richard Schwab3, Michael C Langham1, and Felix W Wehrli1

1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, United States, 3Division of Sleep Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States

Obstructive sleep apnea (OSA) is a chronic disorder caused by intermittent obstruction of the upper airways during sleep. Neurocognitive deficits in this population have previously been associated with altered brain metabolism. In fact, a recent pilot study suggests that global cerebral metabolic rate of oxygen (CMRO2) may be a potential marker of oxygen metabolic dysfunction in this population. Here, we present preliminary results from an ongoing study designed to quantify CMRO2 in subjects with OSA and matched controls. Initial results suggest that apneics have overall lower baseline CMRO2 and increased response to volitional apnea, a paradigm to mimic spontaneous apneas.

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