Abstract #4653

Correlation between dynamic changes of glutamate metabolism and microcirculatory perfusion in basal ganglia after hypoxic–ischemic brain damage

Yuxue Dang¹, Xiaoming Wang², and Kaining Shi³

¹Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China, ²Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, China, People's Republic of China, ³Department of Imaging Systems Clinical Science, Philips Healthcare (China), Beijing, People's Republic of China

The excitotoxicity of glutamate metabolism as well as hemodynamic disorders of the brain are both risk factors for neonatal hypoxic–ischemic brain damage (HIBD). To investigate the combined application of intravoxel incoherent motion (IVIM) and ¹H-magnetic resonance spectroscopy (MRS) in exploring the possible mechanisms. This study was undertaken to examine basal ganglia metabolites (by means of ¹H MRS) and microcirculation (by means of IVIM) in a piglet model of hypoxic-ischemia (HI). It is concluded that elevation of glutamate occurs in parallel to perfusion disruption reflected by changes in perfusion fraction f after HI.

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