Abstract #4652

A metabolic study of hypoxic ischemia during mouse brain development using hyperpolarized 13C

Yiran Chen^1,2, Byongsop Lee^3,4, Robert Bok¹, Ilwoo Park¹, Subramaniam Sukumar¹, R Ann Sheldon^3,4, A James Barkovich^1,4, Donna M Ferriero^3,4, and Duan Xu^1,2

¹Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, ²Joint UCSF/UC Berkeley Graduate Group in Bioengineering, UCSF, San Francisco, CA, United States, ³Department of Neurology, UCSF, San Francisco, CA, United States, ⁴Department of Pediatrics, UCSF, San Francisco, CA, United States

In this study, we applied dynamic nuclear polarization (DNP) technique to investigate C1 labeled ¹³C pyruvate to lactate conversion on hypoxic ischemia (HI) injured neonatal mouse brains during development. Our results showed that lower pyruvate level and higher lactate to pyruvate ratio on the injured hemisphere in comparison to the non-injured hemisphere at the day of injury (P10). This difference narrows as the brain matures. With this technique, we are able to examine individuals’ response to HI in vivo during brain development.

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