Abstract #4651

Longitudinal Changes of Metabolites Measured by Proton Magnetic Resonance Spectroscopy and Their Correlations with Behavioral Outcomes in a Rat Model of Kainic Acid Induced Spinal Cord Injury

Mingming Zhu¹, Alice Shum-Siu², Emily Martin², Abby Wade², Darlene Burke², David S Magnuson², and Chin K Ng¹

¹Diagnostic Radiology, University of Louisville School of Medicine, Louisville, KY, United States, ²Neurological Surgery, University of Louisville School of Medicine, Louisville, KY, United States

We measured the profile of major metabolites longitudinally using MRS in spinal cord gray matter of kainic acid (KA) injured rats at both 7 and 14 days post KA administration and correlated their concentrations with functional outcomes assessed by the Basso, Bresnahan, and Beattie (BBB) Open Field Locomotor scores. Our preliminary findings indicate that metabolite concentrations in the lower lumbar spinal cord gray matter, caudal to the injury epicenter, as detected by in vivo 1H-MRS, could be used as injury and recovery biomarkers in SCI animal models.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.