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Abstract #4676

Free Water Estimation Improves in vivo Diffusion MRI Remote from the Lesion Site in Rat Spinal Cord Injury

Matthew Budde1, Nathan Skinner2, Brian Schmit3, and Shekar Kurpad1

1Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States, 2Medical College of Wisconsin, Milwaukee, WI, United States, 3Biomedical Engineering, Marquette University, Milwaukee, WI, United States

Diffusion tensor imaging (DTI) of the spinal cord remote from the site of injury has been shown to be a surrogate marker of spinal cord injury (SCI) severity. In this work, detection of injury severity with in vivo diffusion MRI of the rat cervical cord following a thoracic SCI was improved with advanced diffusion MRI signal modelling compared to DTI.

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