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Abstract #4697

Prenatal exposure to phthalate esters and later brain structure change revealed by generalized q-sampling MRI

Yen-Ning Hsu1, Jun-Cheng Weng1,2, Jeng-Dau Tasi3, Chao-Yu Shen1,2,4, and Shu-Li Wang5

1Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan, 2Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan, 3School of Medicine and Department of Pediatrics, Chung Shan Medical University and Hospital, Taichung, Taiwan, 4Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, 5National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan

Phthalate esters are a group of chemicals that are widely used everywhere. There is an emerging public health issue that the prevalent use of phthalates may affect children’s brain development. Therefore, we tried to use generalized q-sampling imaging (GQI) to identify the neurological structure changes of white matter of children’s brain induced by prenatal phthalate exposure. The altered GQI indices in the corpus callosum, corona radiata, superior longitudinal fasciculus (SLF), internal capsule, and superior frontal gyrus were found in the children’s brain who were prenatal exposure to phthalate esters.

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