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Abstract #4698

Measuring white matter structure in solid tumor survivors: a fixel-based versus voxel-based approach

Charlotte Sleurs1,2, Jurgen Lemiere1, Daan Christiaens3, Thibo Billiet4, Marjolein Verly2, Ronald Peeters2, Stefan Sunaert2, Anne Uyttebroeck1, and Sabine Deprez2

1Department of Pediatric Hematology and Oncology, University Hospitals Leuven, Leuven, Belgium, 2Department of Radiology, University Hospitals Leuven, Leuven, Belgium, 3Centre for the Developing Brain, King’s College London, 4Imaging Biomarker Experts, Icometrix

Neurotoxicity of multi-agent chemotherapy in survivors of solid non-CNS tumors during childhood, has limitedly been investigated. Nowadays, diffusion-weighted imaging (DWI) is implemented in clinical studies to examine potential white matter changes. However, standard voxel-based analyses of diffusion measures such as fractional anisotropy (FA), only provide information about local white matter structure on a voxel-level, but lack specific information about fiber populations within a voxel. Therefore, we compared a fixel-based versus voxel-based group comparison analysis of DWI images in survivors of pediatric solid tumor versus healthy age-matched controls.

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