Abstract #4715

Development of a clinically useful cerebrovascular stress test using CO2 and BOLD-MRI

Olivia Sobczyk¹, James Duffin^2,3, Adrian P Crawley⁴, Kevin Sam⁴, Julien Poublanc⁴, Lashmi Venkatraghavan³, Daniel M Mandell⁴, David J Mikulis^1,4, and Joseph A Fisher^1,2,3

¹Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada, ²Department of Physiology, University of Toronto, Toronto, ON, Canada, ³Department of Anaesthesia and Pain Management, University Health Network, Toronto, ON, Canada, ⁴Joint Department of Medical Imaging and the Functional Neuroimaging Laboratory, University Health Network, Toronto, ON, Canada

Current methods of measuring cerebrovascular reactivity (CVR) have shown promise for aiding in clinical diagnosis and management of patients with various neurovascular diseases. However, CVR measurement is currently limited to a research setting and transition to clinical utility requires a universal standardized measurement method. Using BOLD-MRI CO₂ measured CVR, we present experimentally developed concepts for standardization and post processing, which have the potential to provide a clinically useful brain stress test.

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