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Abstract #4715

Development of a clinically useful cerebrovascular stress test using CO2 and BOLD-MRI

Olivia Sobczyk1, James Duffin2,3, Adrian P Crawley4, Kevin Sam4, Julien Poublanc4, Lashmi Venkatraghavan3, Daniel M Mandell4, David J Mikulis1,4, and Joseph A Fisher1,2,3

1Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada, 2Department of Physiology, University of Toronto, Toronto, ON, Canada, 3Department of Anaesthesia and Pain Management, University Health Network, Toronto, ON, Canada, 4Joint Department of Medical Imaging and the Functional Neuroimaging Laboratory, University Health Network, Toronto, ON, Canada

Current methods of measuring cerebrovascular reactivity (CVR) have shown promise for aiding in clinical diagnosis and management of patients with various neurovascular diseases. However, CVR measurement is currently limited to a research setting and transition to clinical utility requires a universal standardized measurement method. Using BOLD-MRI CO2 measured CVR, we present experimentally developed concepts for standardization and post processing, which have the potential to provide a clinically useful brain stress test.

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